Suicide prevention with lithium or clozapine?
Question: A colleague told me that lithium only prevents suicide in bipolar illness, while clozapine prevents suicide in schizophrenia. Is that true? PL: Lithium was shown to prevent completed suicide in four randomized clinical trials versus placebo in both bipolar illness and unipolar depression, so its benefit is not limited to bipolar illness, but applies to all mood illnesses. Further, the epidemiological water studies, though not randomized, provide reasonable evidence